Assay Detail
Binding
CHEMBL4156508
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Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli assessed as intrinsic Kd in presence of ANS by fluorescent thermal shift assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 29 | 6.77 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160627 | — | — | 1 | 9.39 |
| CHEMBL4176862 | — | — | 1 | 8.63 |
| CHEMBL4168966 | — | — | 1 | 8.43 |
| CHEMBL4170371 | — | — | 1 | 7.82 |
| CHEMBL4170792 | — | — | 1 | 7.82 |
| CHEMBL4163518 | — | — | 1 | 7.70 |
| CHEMBL4176828 | — | — | 1 | 7.58 |
| CHEMBL4161701 | — | — | 1 | 7.51 |
| CHEMBL4162451 | — | — | 1 | 7.43 |
| CHEMBL4165543 | — | — | 1 | 7.31 |
| CHEMBL4165127 | — | — | 1 | 7.08 |
| CHEMBL120886 | — | — | 1 | 6.82 |
| CHEMBL4175740 | — | — | 1 | 6.48 |
| CHEMBL4165570 | — | — | 1 | 6.44 |
| CHEMBL4177268 | — | — | 1 | 6.43 |
| CHEMBL4174214 | — | — | 1 | 6.43 |
| CHEMBL4159066 | — | — | 1 | 6.43 |
| CHEMBL4170058 | — | — | 1 | 6.43 |
| CHEMBL4160149 | — | — | 1 | 6.27 |
| CHEMBL4166964 | — | — | 1 | 6.09 |
| CHEMBL4173501 | — | — | 1 | 6.00 |
| CHEMBL4166643 | — | — | 1 | 5.89 |
| CHEMBL4172331 | — | — | 1 | 5.82 |
| CHEMBL4165896 | — | — | 1 | 5.80 |
| CHEMBL4162133 | — | — | 1 | 5.77 |
| CHEMBL4168997 | — | — | 1 | 5.75 |
| CHEMBL4168586 | — | — | 1 | 5.60 |
| CHEMBL4173471 | — | — | 1 | 5.54 |
| CHEMBL4173814 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160627 | — | Kd | = | 0.41 | nM | 9.39 |
| CHEMBL4176862 | — | Kd | = | 2.34 | nM | 8.63 |
| CHEMBL4168966 | — | Kd | = | 3.7 | nM | 8.43 |
| CHEMBL4170371 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL4170792 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL4163518 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL4176828 | — | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL4161701 | — | Kd | = | 31.0 | nM | 7.51 |
| CHEMBL4162451 | — | Kd | = | 37.0 | nM | 7.43 |
| CHEMBL4165543 | — | Kd | = | 49.0 | nM | 7.31 |
| CHEMBL4165127 | — | Kd | = | 84.0 | nM | 7.08 |
| CHEMBL120886 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL4175740 | — | Kd | = | 330.0 | nM | 6.48 |
| CHEMBL4165570 | — | Kd | = | 360.0 | nM | 6.44 |
| CHEMBL4177268 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL4174214 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL4159066 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL4170058 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL4160149 | — | Kd | = | 540.0 | nM | 6.27 |
| CHEMBL4166964 | — | Kd | = | 810.0 | nM | 6.09 |
| CHEMBL4173501 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL4166643 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL4172331 | — | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL4165896 | — | Kd | = | 1600.0 | nM | 5.80 |
| CHEMBL4162133 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL4168997 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL4168586 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL4173471 | — | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL4173814 | — | Kd | = | 3200.0 | nM | 5.50 |