Assay Detail
Binding
CHEMBL4156510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human carbonic anhydrase 3 (4 to 260 residues) expressed in Escherichia coli BL21 (DE3) strain assessed as intrinsic Kd in presence of ANS by fluorescent thermal shift assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 29 | 7.28 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170792 | — | — | 1 | 8.12 |
| CHEMBL4165570 | — | — | 1 | 8.12 |
| CHEMBL120886 | — | — | 1 | 8.08 |
| CHEMBL4161701 | — | — | 1 | 8.02 |
| CHEMBL4165127 | — | — | 1 | 7.77 |
| CHEMBL4160627 | — | — | 1 | 7.72 |
| CHEMBL4168966 | — | — | 1 | 7.52 |
| CHEMBL4160149 | — | — | 1 | 7.52 |
| CHEMBL4163518 | — | — | 1 | 7.52 |
| CHEMBL4176862 | — | — | 1 | 7.52 |
| CHEMBL4172331 | — | — | 1 | 7.51 |
| CHEMBL4166643 | — | — | 1 | 7.43 |
| CHEMBL4170371 | — | — | 1 | 7.42 |
| CHEMBL4168997 | — | — | 1 | 7.40 |
| CHEMBL4175740 | — | — | 1 | 7.36 |
| CHEMBL4162451 | — | — | 1 | 7.32 |
| CHEMBL4166964 | — | — | 1 | 7.29 |
| CHEMBL4165543 | — | — | 1 | 7.22 |
| CHEMBL4173471 | — | — | 1 | 7.03 |
| CHEMBL4170058 | — | — | 1 | 7.02 |
| CHEMBL4177268 | — | — | 1 | 7.02 |
| CHEMBL4159066 | — | — | 1 | 7.02 |
| CHEMBL4174214 | — | — | 1 | 7.02 |
| CHEMBL4168586 | — | — | 1 | 6.82 |
| CHEMBL4165896 | — | — | 1 | 6.68 |
| CHEMBL4162133 | — | — | 1 | 6.66 |
| CHEMBL4176828 | — | — | 1 | 6.62 |
| CHEMBL4173814 | — | — | 1 | 6.38 |
| CHEMBL4173501 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170792 | — | Kd | = | 7.6 | nM | 8.12 |
| CHEMBL4165570 | — | Kd | = | 7.5 | nM | 8.12 |
| CHEMBL120886 | — | Kd | = | 8.4 | nM | 8.08 |
| CHEMBL4161701 | — | Kd | = | 9.6 | nM | 8.02 |
| CHEMBL4165127 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL4160627 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL4168966 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL4160149 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL4163518 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL4176862 | — | Kd | = | 30.3 | nM | 7.52 |
| CHEMBL4172331 | — | Kd | = | 31.0 | nM | 7.51 |
| CHEMBL4166643 | — | Kd | = | 37.0 | nM | 7.43 |
| CHEMBL4170371 | — | Kd | = | 38.0 | nM | 7.42 |
| CHEMBL4168997 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL4175740 | — | Kd | = | 44.0 | nM | 7.36 |
| CHEMBL4162451 | — | Kd | = | 48.0 | nM | 7.32 |
| CHEMBL4166964 | — | Kd | = | 51.0 | nM | 7.29 |
| CHEMBL4165543 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL4173471 | — | Kd | = | 94.0 | nM | 7.03 |
| CHEMBL4170058 | — | Kd | = | 96.0 | nM | 7.02 |
| CHEMBL4177268 | — | Kd | = | 96.0 | nM | 7.02 |
| CHEMBL4159066 | — | Kd | = | 96.0 | nM | 7.02 |
| CHEMBL4174214 | — | Kd | = | 96.0 | nM | 7.02 |
| CHEMBL4168586 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL4165896 | — | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL4162133 | — | Kd | = | 220.0 | nM | 6.66 |
| CHEMBL4176828 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL4173814 | — | Kd | = | 420.0 | nM | 6.38 |
| CHEMBL4173501 | — | Kd | = | 750.0 | nM | 6.12 |