Assay Detail
Binding
CHEMBL4156513
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) strain assessed as intrinsic Kd in presence of ANS by fluorescent thermal shift assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5B, mitochondrial (CHEMBL3969) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 29 | 8.55 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165570 | — | — | 1 | 10.22 |
| CHEMBL4166643 | — | — | 1 | 9.96 |
| CHEMBL4176862 | — | — | 1 | 9.43 |
| CHEMBL4165896 | — | — | 1 | 9.24 |
| CHEMBL4173501 | — | — | 1 | 9.22 |
| CHEMBL4168966 | — | — | 1 | 9.20 |
| CHEMBL4175740 | — | — | 1 | 9.15 |
| CHEMBL4160149 | — | — | 1 | 9.14 |
| CHEMBL4165127 | — | — | 1 | 8.96 |
| CHEMBL4168997 | — | — | 1 | 8.92 |
| CHEMBL4174214 | — | — | 1 | 8.92 |
| CHEMBL4170371 | — | — | 1 | 8.85 |
| CHEMBL4166964 | — | — | 1 | 8.66 |
| CHEMBL4163518 | — | — | 1 | 8.62 |
| CHEMBL4170792 | — | — | 1 | 8.62 |
| CHEMBL4172331 | — | — | 1 | 8.51 |
| CHEMBL120886 | — | — | 1 | 8.41 |
| CHEMBL4173471 | — | — | 1 | 8.22 |
| CHEMBL4162133 | — | — | 1 | 8.21 |
| CHEMBL4159066 | — | — | 1 | 8.18 |
| CHEMBL4162451 | — | — | 1 | 7.92 |
| CHEMBL4168586 | — | — | 1 | 7.80 |
| CHEMBL4165543 | — | — | 1 | 7.70 |
| CHEMBL4173814 | — | — | 1 | 7.46 |
| CHEMBL4160627 | — | — | 1 | 7.40 |
| CHEMBL4176828 | — | — | 1 | 7.30 |
| CHEMBL4161701 | — | — | 1 | 6.70 |
| CHEMBL4177268 | — | — | 1 | - |
| CHEMBL4170058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165570 | — | Kd | = | 0.06 | nM | 10.22 |
| CHEMBL4166643 | — | Kd | = | 0.11 | nM | 9.96 |
| CHEMBL4176862 | — | Kd | = | 0.37 | nM | 9.43 |
| CHEMBL4165896 | — | Kd | = | 0.58 | nM | 9.24 |
| CHEMBL4173501 | — | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL4168966 | — | Kd | = | 0.63 | nM | 9.20 |
| CHEMBL4175740 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL4160149 | — | Kd | = | 0.73 | nM | 9.14 |
| CHEMBL4165127 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL4168997 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL4174214 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL4170371 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL4166964 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL4163518 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL4170792 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL4172331 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL120886 | — | Kd | = | 3.9 | nM | 8.41 |
| CHEMBL4173471 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL4162133 | — | Kd | = | 6.1 | nM | 8.21 |
| CHEMBL4159066 | — | Kd | = | 6.6 | nM | 8.18 |
| CHEMBL4162451 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL4168586 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL4165543 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL4173814 | — | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL4160627 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL4176828 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL4161701 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL4177268 | — | Kd | - | — | - | |
| CHEMBL4170058 | — | Kd | - | — | - |