Assay Detail
Binding
CHEMBL4156515
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Binding affinity to recombinant N-terminal His-tagged human carbonic anhydrase 7 (3 to 264 residues) expressed in Escherichia coli BL21 (DE3) strain assessed as intrinsic Kd in presence of ANS by fluorescent thermal shift assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 29 | 9.50 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170792 | — | — | 1 | 10.80 |
| CHEMBL4160149 | — | — | 1 | 10.52 |
| CHEMBL4165570 | — | — | 1 | 10.52 |
| CHEMBL4176862 | — | — | 1 | 10.51 |
| CHEMBL4166643 | — | — | 1 | 10.49 |
| CHEMBL4170371 | — | — | 1 | 10.42 |
| CHEMBL4168966 | — | — | 1 | 10.26 |
| CHEMBL4172331 | — | — | 1 | 10.22 |
| CHEMBL4173471 | — | — | 1 | 10.22 |
| CHEMBL4168997 | — | — | 1 | 10.19 |
| CHEMBL4166964 | — | — | 1 | 10.12 |
| CHEMBL4175740 | — | — | 1 | 9.92 |
| CHEMBL4162133 | — | — | 1 | 9.92 |
| CHEMBL4163518 | — | — | 1 | 9.92 |
| CHEMBL120886 | — | — | 1 | 9.85 |
| CHEMBL4165896 | — | — | 1 | 9.85 |
| CHEMBL4173501 | — | — | 1 | 9.77 |
| CHEMBL4173814 | — | — | 1 | 9.64 |
| CHEMBL4165127 | — | — | 1 | 9.62 |
| CHEMBL4168586 | — | — | 1 | 9.47 |
| CHEMBL4165543 | — | — | 1 | 9.06 |
| CHEMBL4160627 | — | — | 1 | 9.00 |
| CHEMBL4159066 | — | — | 1 | 8.82 |
| CHEMBL4162451 | — | — | 1 | 8.66 |
| CHEMBL4176828 | — | — | 1 | 8.59 |
| CHEMBL4174214 | — | — | 1 | 7.89 |
| CHEMBL4161701 | — | — | 1 | 7.72 |
| CHEMBL4177268 | — | — | 1 | 6.82 |
| CHEMBL4170058 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170792 | — | Kd | = | 0.016 | nM | 10.80 |
| CHEMBL4160149 | — | Kd | = | 0.03 | nM | 10.52 |
| CHEMBL4165570 | — | Kd | = | 0.03 | nM | 10.52 |
| CHEMBL4176862 | — | Kd | = | 0.031 | nM | 10.51 |
| CHEMBL4166643 | — | Kd | = | 0.032 | nM | 10.49 |
| CHEMBL4170371 | — | Kd | = | 0.038 | nM | 10.42 |
| CHEMBL4168966 | — | Kd | = | 0.055 | nM | 10.26 |
| CHEMBL4172331 | — | Kd | = | 0.06 | nM | 10.22 |
| CHEMBL4173471 | — | Kd | = | 0.06 | nM | 10.22 |
| CHEMBL4168997 | — | Kd | = | 0.064 | nM | 10.19 |
| CHEMBL4166964 | — | Kd | = | 0.075 | nM | 10.12 |
| CHEMBL4175740 | — | Kd | = | 0.12 | nM | 9.92 |
| CHEMBL4162133 | — | Kd | = | 0.12 | nM | 9.92 |
| CHEMBL4163518 | — | Kd | = | 0.12 | nM | 9.92 |
| CHEMBL120886 | — | Kd | = | 0.14 | nM | 9.85 |
| CHEMBL4165896 | — | Kd | = | 0.14 | nM | 9.85 |
| CHEMBL4173501 | — | Kd | = | 0.17 | nM | 9.77 |
| CHEMBL4173814 | — | Kd | = | 0.23 | nM | 9.64 |
| CHEMBL4165127 | — | Kd | = | 0.24 | nM | 9.62 |
| CHEMBL4168586 | — | Kd | = | 0.34 | nM | 9.47 |
| CHEMBL4165543 | — | Kd | = | 0.88 | nM | 9.06 |
| CHEMBL4160627 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL4159066 | — | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL4162451 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL4176828 | — | Kd | = | 2.6 | nM | 8.59 |
| CHEMBL4174214 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL4161701 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL4177268 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL4170058 | — | Kd | = | 150.0 | nM | 6.82 |