Assay Detail
ADMET
CHEMBL4156524
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability by measuring ATP level by ATPlite assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.63 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3715235 | — | — | 1 | 5.03 |
| CHEMBL3717389 | — | — | 1 | 4.73 |
| CHEMBL3716980 | — | — | 1 | 4.73 |
| CHEMBL3717211 | — | — | 1 | 4.53 |
| CHEMBL3718400 | — | — | 1 | 4.53 |
| CHEMBL3715081 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3715235 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL3717389 | — | EC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL3716980 | — | EC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL3717211 | — | EC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL3718400 | — | EC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL3715081 | — | EC50 | = | 59300.0 | nM | 4.23 |