Assay Detail
Binding
CHEMBL4156659
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Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.46 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161876 | — | — | 1 | 8.16 |
| CHEMBL4174756 | — | — | 1 | 7.90 |
| CHEMBL4160802 | — | — | 1 | 7.50 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.16 |
| CHEMBL4172196 | — | — | 1 | 7.09 |
| CHEMBL4169404 | — | — | 1 | 6.96 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161876 | — | IC50 | = | 6.85 | nM | 8.16 |
| CHEMBL4174756 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL4160802 | — | IC50 | = | 31.68 | nM | 7.50 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 69.8 | nM | 7.16 |
| CHEMBL4172196 | — | IC50 | = | 81.42 | nM | 7.09 |
| CHEMBL4169404 | — | IC50 | = | 110.45 | nM | 6.96 |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - |