Assay Detail
Functional
CHEMBL4156727
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells after 48 hrs by SRB assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.18 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165442 | — | — | 1 | 5.72 |
| CHEMBL4177341 | — | — | 1 | 5.72 |
| CHEMBL4165649 | — | — | 1 | 5.68 |
| CHEMBL4170545 | — | — | 1 | 5.57 |
| CHEMBL4166496 | — | — | 1 | 5.54 |
| CHEMBL406837 | — | — | 1 | 5.51 |
| CHEMBL4173577 | — | — | 1 | 5.50 |
| CHEMBL4168865 | — | — | 1 | 5.46 |
| CHEMBL1254091 | — | — | 1 | 5.46 |
| CHEMBL4162002 | — | — | 1 | 5.38 |
| CHEMBL571085 | — | — | 1 | 5.36 |
| CHEMBL4170119 | — | — | 1 | 5.24 |
| CHEMBL4169926 | — | — | 1 | 5.13 |
| CHEMBL4162209 | — | — | 1 | 5.12 |
| CHEMBL4173357 | — | — | 1 | 5.11 |
| CHEMBL243829 | FLAVOKAWAIN A | — | 1 | 4.97 |
| CHEMBL4176724 | — | — | 1 | 4.93 |
| CHEMBL4096192 | — | — | 1 | 4.85 |
| CHEMBL4170314 | — | — | 1 | 4.82 |
| CHEMBL4177119 | — | — | 1 | 4.61 |
| CHEMBL243830 | — | — | 1 | 4.56 |
| CHEMBL4159688 | — | — | 1 | 4.53 |
| CHEMBL3393847 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165442 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4177341 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4165649 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4170545 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4166496 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL406837 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4173577 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4168865 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1254091 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4162002 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL571085 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4170119 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4169926 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4162209 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4173357 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL243829 | FLAVOKAWAIN A | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4176724 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4096192 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4170314 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL4177119 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL243830 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL4159688 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL3393847 | — | IC50 | = | 50000.0 | nM | 4.30 |