Assay Detail
Binding
CHEMBL4157375
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Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by spectrometric analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.37 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161583 | — | — | 1 | 5.96 |
| CHEMBL4176281 | — | — | 1 | 5.89 |
| CHEMBL4167333 | — | — | 1 | 5.82 |
| CHEMBL4160098 | — | — | 1 | 5.66 |
| CHEMBL4162794 | — | — | 1 | 5.62 |
| CHEMBL4161487 | — | — | 1 | 5.58 |
| CHEMBL4168415 | — | — | 1 | 5.51 |
| CHEMBL4166077 | — | — | 1 | 5.29 |
| CHEMBL4169499 | — | — | 1 | 5.28 |
| CHEMBL4176697 | — | — | 1 | 5.17 |
| CHEMBL4168023 | — | — | 1 | 5.00 |
| CHEMBL3970551 | — | — | 1 | 4.96 |
| CHEMBL3975683 | — | — | 1 | 4.82 |
| CHEMBL3955935 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161583 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4176281 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4167333 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4160098 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4162794 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4161487 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4168415 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4166077 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4169499 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4176697 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4168023 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3970551 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3975683 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3955935 | — | IC50 | = | 24000.0 | nM | 4.62 |