Assay Detail
Binding
CHEMBL4157378
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Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 40 to 60 mins by spectrometric analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.10 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161583 | — | — | 1 | 6.00 |
| CHEMBL4167333 | — | — | 1 | 5.68 |
| CHEMBL4169499 | — | — | 1 | 5.62 |
| CHEMBL4160098 | — | — | 1 | 5.35 |
| CHEMBL4166077 | — | — | 1 | 5.33 |
| CHEMBL4176697 | — | — | 1 | 5.30 |
| CHEMBL4162794 | — | — | 1 | 5.23 |
| CHEMBL4161487 | — | — | 1 | 5.21 |
| CHEMBL4168023 | — | — | 1 | 4.96 |
| CHEMBL3955935 | — | — | 1 | 4.29 |
| CHEMBL3970551 | — | — | 1 | 4.24 |
| CHEMBL3975683 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161583 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4167333 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4169499 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4160098 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4166077 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4176697 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4162794 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4161487 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4168023 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3955935 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3970551 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL3975683 | — | IC50 | = | 96000.0 | nM | 4.02 |