Assay Detail
Functional
CHEMBL4157384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 infected in human MT2 cells after 4 to 5 days in presence of 10% FBS and 40% human serum albumin by dual luciferase reporter gene assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.58 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827026 | — | — | 1 | 8.24 |
| CHEMBL4171754 | — | — | 1 | 8.21 |
| CHEMBL4164969 | — | — | 1 | 8.13 |
| CHEMBL4176670 | — | — | 1 | 7.96 |
| CHEMBL4167605 | — | — | 1 | 7.89 |
| CHEMBL4168814 | — | — | 1 | 7.86 |
| CHEMBL4163873 | — | — | 1 | 7.80 |
| CHEMBL4161554 | — | — | 1 | 7.67 |
| CHEMBL4170377 | — | — | 1 | 7.63 |
| CHEMBL4172161 | — | — | 1 | 7.61 |
| CHEMBL4160495 | — | — | 1 | 7.58 |
| CHEMBL4171833 | — | — | 1 | 7.46 |
| CHEMBL4163521 | — | — | 1 | 7.43 |
| CHEMBL3786166 | — | — | 1 | 6.35 |
| CHEMBL4163247 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827026 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4171754 | — | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4164969 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4176670 | — | EC50 | = | 11.1 | nM | 7.96 |
| CHEMBL4167605 | — | EC50 | = | 12.8 | nM | 7.89 |
| CHEMBL4168814 | — | EC50 | = | 13.7 | nM | 7.86 |
| CHEMBL4163873 | — | EC50 | = | 15.9 | nM | 7.80 |
| CHEMBL4161554 | — | EC50 | = | 21.3 | nM | 7.67 |
| CHEMBL4170377 | — | EC50 | = | 23.6 | nM | 7.63 |
| CHEMBL4172161 | — | EC50 | = | 24.5 | nM | 7.61 |
| CHEMBL4160495 | — | EC50 | = | 26.1 | nM | 7.58 |
| CHEMBL4171833 | — | EC50 | = | 35.1 | nM | 7.46 |
| CHEMBL4163521 | — | EC50 | = | 37.5 | nM | 7.43 |
| CHEMBL3786166 | — | EC50 | = | 449.0 | nM | 6.35 |
| CHEMBL4163247 | — | EC50 | = | 1291.0 | nM | 5.89 |