Assay Detail
Functional
CHEMBL4157385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 expressing gag V370A mutant infected in human MT2 cells after 4 to 5 days by dual luciferase reporter gene assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 8.16 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160947 | — | — | 1 | 8.85 |
| CHEMBL4163064 | — | — | 1 | 8.82 |
| CHEMBL3827026 | — | — | 1 | 8.60 |
| CHEMBL4161218 | — | — | 1 | 8.60 |
| CHEMBL4171754 | — | — | 1 | 8.57 |
| CHEMBL3827379 | BMS-955176 | 2.0 | 1 | 8.57 |
| CHEMBL4176670 | — | — | 1 | 8.55 |
| CHEMBL4170983 | — | — | 1 | 8.54 |
| CHEMBL4167605 | — | — | 1 | 8.47 |
| CHEMBL4174855 | — | — | 1 | 8.46 |
| CHEMBL4163873 | — | — | 1 | 8.43 |
| CHEMBL4164785 | — | — | 1 | 8.31 |
| CHEMBL4166969 | — | — | 1 | 8.30 |
| CHEMBL4160495 | — | — | 1 | 8.28 |
| CHEMBL4175001 | — | — | 1 | 8.26 |
| CHEMBL4159740 | — | — | 1 | 8.15 |
| CHEMBL4170377 | — | — | 1 | 8.12 |
| CHEMBL4171418 | — | — | 1 | 8.00 |
| CHEMBL4175595 | — | — | 1 | 8.00 |
| CHEMBL4168390 | — | — | 1 | 7.99 |
| CHEMBL4164349 | — | — | 1 | 7.97 |
| CHEMBL4172680 | — | — | 1 | 7.95 |
| CHEMBL4168071 | — | — | 1 | 7.88 |
| CHEMBL4160156 | — | — | 1 | 7.85 |
| CHEMBL3786166 | — | — | 1 | 6.37 |
| CHEMBL4163247 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160947 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4163064 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3827026 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4161218 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4171754 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3827379 | BMS-955176 | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4176670 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4170983 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4167605 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4174855 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4163873 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4164785 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4166969 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4160495 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4175001 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4159740 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4170377 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4171418 | — | EC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4175595 | — | EC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4168390 | — | EC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4164349 | — | EC50 | = | 10.7 | nM | 7.97 |
| CHEMBL4172680 | — | EC50 | = | 11.2 | nM | 7.95 |
| CHEMBL4168071 | — | EC50 | = | 13.2 | nM | 7.88 |
| CHEMBL4160156 | — | EC50 | = | 14.1 | nM | 7.85 |
| CHEMBL3786166 | — | EC50 | = | 427.0 | nM | 6.37 |
| CHEMBL4163247 | — | EC50 | = | 552.0 | nM | 6.26 |