Assay Detail
Binding
CHEMBL4157899
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Displacement of ARC-1504/ARC-1513-5O from CK2alpha (unknown origin) (1 to 335 residues) after 15 to 60 mins by luminescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.90 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4162173 | — | — | 1 | 9.47 |
| CHEMBL4169451 | — | — | 1 | 9.40 |
| CHEMBL4177303 | — | — | 1 | 9.24 |
| CHEMBL4172847 | — | — | 1 | 9.07 |
| CHEMBL4166028 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4162173 | — | Kd | = | 0.34 | nM | 9.47 |
| CHEMBL4169451 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL4177303 | — | Kd | = | 0.58 | nM | 9.24 |
| CHEMBL4172847 | — | Kd | = | 0.85 | nM | 9.07 |
| CHEMBL4166028 | — | Kd | = | 48.0 | nM | 7.32 |