Compound Detail
CHEMBL4172847
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CN(C)c1ccc2c(-c3ccc(C(=O)NCCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)CCCCCNC(=O)CCC(=O)Nc4ncc(-c5ccc(C(=O)O)cc5)[se]4)C(=O)O)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1
Basic Information
| ChEMBL ID | CHEMBL4172847 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UOJDTCHIIGZJHW-ZMPVPJHUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1711.5
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 9.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Casein kinase II subunit alpha CHEMBL3629 | Kd | 9.07 | 9.07 | 0.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Casein kinase II subunit alpha | Kd | = | 0.85 | nM | 9.07 | Displacement of ARC-1504/ARC-1513-5O from CK2alpha (unknown origin) (1 to 335 re... | 30217463 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30217463 | 10.1016/j.bmc.2018.09.003 | Casein kinase II subunit alpha | 7 |
| 30217463 | 10.1016/j.bmc.2018.09.003 | Casein kinase II subunit alpha' | 2 |
| 30217463 | 10.1016/j.bmc.2018.09.003 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine