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Assay Detail

CHEMBL4158080

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antagonist activity at AR in mouse SC3 cells assessed as inhibition of DHT-induced cell proliferation after 3 days by CCK8 assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Androgen receptor (CHEMBL3056)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Structure-activity relationship of novel (benzoylaminophenoxy)phenol derivatives as anti-prostate cancer agents.
Kazui Y, Fujii S, Yamada A, Ishigami-Yuasa M, Kagechika H, Tanatani A.
Bioorg Med Chem (2018) 26 : 5118 -5127
PubMed 30228001 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.74 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4173412 1 6.40
CHEMBL4166357 1 6.32
CHEMBL4161797 1 6.32
CHEMBL4174659 1 6.29
CHEMBL4174266 1 6.28
CHEMBL4162851 1 6.19
CHEMBL2441094 1 6.12
CHEMBL4167449 1 5.77
CHEMBL4171945 1 5.52
CHEMBL4167057 1 5.50
CHEMBL4159542 1 5.47
CHEMBL4165227 1 5.37
CHEMBL4165873 1 5.28
CHEMBL4169720 1 5.24
CHEMBL4173904 1 5.20
CHEMBL4159042 1 5.13
CHEMBL4168648 1 5.12
CHEMBL4164795 1 -
CHEMBL4161383 1 -
CHEMBL4169303 1 -
CHEMBL4173107 1 -
CHEMBL4162430 1 -
CHEMBL4169699 1 -
CHEMBL4171502 1 -
CHEMBL4174938 1 -
CHEMBL4160251 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4173412 IC50 = 400.0 nM 6.40
CHEMBL4166357 IC50 = 480.0 nM 6.32
CHEMBL4161797 IC50 = 480.0 nM 6.32
CHEMBL4174659 IC50 = 510.0 nM 6.29
CHEMBL4174266 IC50 = 530.0 nM 6.28
CHEMBL4162851 IC50 = 650.0 nM 6.19
CHEMBL2441094 IC50 = 750.0 nM 6.12
CHEMBL4167449 IC50 = 1700.0 nM 5.77
CHEMBL4171945 IC50 = 3000.0 nM 5.52
CHEMBL4167057 IC50 = 3200.0 nM 5.50
CHEMBL4159542 IC50 = 3400.0 nM 5.47
CHEMBL4165227 IC50 = 4300.0 nM 5.37
CHEMBL4165873 IC50 = 5300.0 nM 5.28
CHEMBL4169720 IC50 = 5700.0 nM 5.24
CHEMBL4173904 IC50 = 6300.0 nM 5.20
CHEMBL4159042 IC50 = 7400.0 nM 5.13
CHEMBL4168648 IC50 = 7600.0 nM 5.12
CHEMBL4164795 IC50 > 10000.0 nM -
CHEMBL4161383 IC50 > 10000.0 nM -
CHEMBL4169303 IC50 > 10000.0 nM -
CHEMBL4173107 IC50 > 10000.0 nM -
CHEMBL4162430 IC50 > 10000.0 nM -
CHEMBL4169699 IC50 > 10000.0 nM -
CHEMBL4171502 IC50 > 10000.0 nM -
CHEMBL4174938 IC50 > 10000.0 nM -
CHEMBL4160251 IC50 > 10000.0 nM -