Assay Detail
Binding
CHEMBL4158215
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Inhibition of recombinant human full length MMP13 expressed in mouse NS0 cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.62 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164242 | — | — | 1 | 8.80 |
| CHEMBL4172893 | — | — | 1 | 8.72 |
| CHEMBL4169495 | — | — | 1 | 8.62 |
| CHEMBL4172563 | — | — | 1 | 8.60 |
| CHEMBL4172804 | — | — | 1 | 8.60 |
| CHEMBL4080520 | — | — | 1 | 8.57 |
| CHEMBL4170562 | — | — | 1 | 8.36 |
| CHEMBL4088383 | — | — | 1 | 8.36 |
| CHEMBL4159255 | — | — | 1 | 8.29 |
| CHEMBL4173661 | — | — | 1 | 8.26 |
| CHEMBL4175968 | — | — | 1 | 8.19 |
| CHEMBL4159992 | — | — | 1 | 8.19 |
| CHEMBL4165747 | — | — | 1 | 8.16 |
| CHEMBL4177034 | — | — | 1 | 8.15 |
| CHEMBL4176183 | — | — | 1 | 8.15 |
| CHEMBL4165348 | — | — | 1 | 8.14 |
| CHEMBL4172564 | — | — | 1 | 8.11 |
| CHEMBL4164676 | — | — | 1 | 8.08 |
| CHEMBL4164905 | — | — | 1 | 8.07 |
| CHEMBL4161914 | — | — | 1 | 8.04 |
| CHEMBL4168115 | — | — | 1 | 8.03 |
| CHEMBL4168477 | — | — | 1 | 7.89 |
| CHEMBL4169179 | — | — | 1 | 7.89 |
| CHEMBL4169181 | — | — | 1 | 7.84 |
| CHEMBL4161070 | — | — | 1 | 7.75 |
| CHEMBL4167912 | — | — | 1 | 7.73 |
| CHEMBL4162629 | — | — | 1 | 7.70 |
| CHEMBL4175116 | — | — | 1 | 7.42 |
| CHEMBL4168336 | — | — | 1 | 7.37 |
| CHEMBL4160072 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164242 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4172893 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4169495 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4172563 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4172804 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4080520 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4170562 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4088383 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4159255 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4173661 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4175968 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4159992 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4165747 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4177034 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4176183 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4165348 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4172564 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4164676 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4164905 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4161914 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4168115 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL4169179 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4168477 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL4169181 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL4161070 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4167912 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL4162629 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4175116 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4168336 | — | IC50 | = | 43.2 | nM | 7.37 |
| CHEMBL4160072 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4164482 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL4162305 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4060150 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL4098541 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4176358 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL4162222 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL4175967 | — | IC50 | = | 697.0 | nM | 6.16 |
| CHEMBL4171334 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4167998 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4165744 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4172976 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4161253 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4172116 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4167168 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4171677 | — | IC50 | > | 5000.0 | nM | - |