Assay Detail
Binding
CHEMBL4158239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human cytosolic PTPepsilon expressed in Escherichia coli BL21 (DE3) using E527-P-Q-pY530-Q-P-G-E-N-L536 as substrate after 60 mins by malachite green assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Receptor-type tyrosine-protein phosphatase epsilon (CHEMBL4850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of N-(5-(phenoxymethyl)-1,3,4-thiadiazol-2-yl)acetamide derivatives as novel protein tyrosine phosphatase epsilon inhibitors exhibiting anti-osteoclastic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.57 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4174865 | — | — | 1 | 5.73 |
| CHEMBL4160163 | — | — | 1 | 5.70 |
| CHEMBL4170383 | — | — | 1 | 5.61 |
| CHEMBL4168082 | — | — | 1 | 5.43 |
| CHEMBL4159748 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4174865 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL4160163 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL4170383 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4168082 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4159748 | — | IC50 | = | 4170.0 | nM | 5.38 |