Assay Detail
Binding
CHEMBL4158335
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Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in presence of SAM by MTase glo methyltransferase assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.47 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4174978 | — | — | 1 | 8.70 |
| CHEMBL4167128 | — | — | 1 | 8.70 |
| CHEMBL4170443 | — | — | 1 | 8.50 |
| CHEMBL4172614 | — | — | 1 | 8.40 |
| CHEMBL4171117 | — | — | 1 | 8.40 |
| CHEMBL4169861 | — | — | 1 | 8.20 |
| CHEMBL4177089 | — | — | 1 | 8.20 |
| CHEMBL4160303 | — | — | 1 | 8.10 |
| CHEMBL4163421 | — | — | 1 | 8.00 |
| CHEMBL4174102 | — | — | 1 | 7.70 |
| CHEMBL4174117 | — | — | 1 | 7.70 |
| CHEMBL4176008 | — | — | 1 | 7.70 |
| CHEMBL4162990 | — | — | 1 | 7.30 |
| CHEMBL4166574 | — | — | 1 | 7.20 |
| CHEMBL4176890 | — | — | 1 | 7.10 |
| CHEMBL4174751 | — | — | 1 | 6.70 |
| CHEMBL4175239 | — | — | 1 | 6.60 |
| CHEMBL4164621 | — | — | 1 | 6.50 |
| CHEMBL4173001 | — | — | 1 | 5.90 |
| CHEMBL310555 | OXYQUINOLINE | -1.0 | 1 | 5.80 |
| CHEMBL4163083 | — | — | 1 | 5.40 |
| CHEMBL4165800 | — | — | 1 | - |
| CHEMBL4162599 | — | — | 1 | - |
| CHEMBL4173789 | — | — | 1 | - |
| CHEMBL4176829 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4174978 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL4167128 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL4170443 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL4172614 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4171117 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4169861 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4177089 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4160303 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL4163421 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4174102 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4174117 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4176008 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4162990 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL4166574 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4176890 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4174751 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4175239 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4164621 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4173001 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL310555 | OXYQUINOLINE | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4163083 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL4165800 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162599 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4173789 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4176829 | — | IC50 | > | 10000.0 | nM | - |