Assay Detail
Binding
CHEMBL4158339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-terminal hexa-His tagged rat S-COMT expressed in HEK293-6E cell membrane homogenate using 7,8-dihydroxy-4-methylcoumarin as substrate after 1 hr in presence of SAM by MTase glo methyltransferase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.25 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172614 | — | — | 1 | 5.40 |
| CHEMBL4167128 | — | — | 1 | 5.10 |
| CHEMBL4171117 | — | — | 1 | - |
| CHEMBL4176008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172614 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL4167128 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4171117 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4176008 | — | IC50 | > | 10000.0 | nM | - |