Assay Detail
Binding
CHEMBL4158657
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorometric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Schistosoma mansoni |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.64 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178342 | — | — | 1 | 7.02 |
| CHEMBL4160522 | — | — | 1 | 7.01 |
| CHEMBL2105763 | QUISINOSTAT | 2.0 | 1 | 6.52 |
| CHEMBL2170177 | — | — | 1 | 6.36 |
| CHEMBL4176696 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178342 | — | IC50 | = | 95.4 | nM | 7.02 |
| CHEMBL4160522 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL2105763 | QUISINOSTAT | IC50 | = | 303.4 | nM | 6.52 |
| CHEMBL2170177 | — | IC50 | = | 435.8 | nM | 6.36 |
| CHEMBL4176696 | — | IC50 | = | 504.0 | nM | 6.30 |