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Assay Detail

CHEMBL4158866

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Binding
Inhibition of Influenza A (A/California/04/2009) (H1N1) clinical isolate N-terminal truncated PA endonuclease using 5'-FAM/3-TAMRA quencer labeled 17-mer ssDNA-oligo as substrate measured over 45 mins by FRET assay
ChEMBL ↗
65
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza A virus (A/California/04/2009(H1N1))
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease.
Credille CV, Dick BL, Morrison CN, Stokes RW, Adamek RN, Wu NC, Wilson IA, Cohen SM.
J Med Chem (2018) 61 : 10206 -10217
PubMed 30351002 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 65 5.94 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4167809 — — 2 8.10
CHEMBL3357560 — — 2 8.00
CHEMBL4168262 — — 2 7.43
CHEMBL4173478 — — 2 7.40
CHEMBL109448 — — 2 7.20
CHEMBL4168851 — — 2 7.10
CHEMBL374569 — — 2 6.60
CHEMBL4176706 — — 2 6.40
CHEMBL463590 — — 1 6.37
CHEMBL4171599 — — 2 6.30
CHEMBL4163716 — — 2 5.92
CHEMBL307145 PYROGALLOL -1.0 2 5.80
CHEMBL4167174 — — 2 5.60
CHEMBL1650617 — — 2 5.50
CHEMBL4159916 — — 2 5.42
CHEMBL4163471 — — 2 5.41
CHEMBL288114 GALLIC ACID 2.0 2 5.40
CHEMBL1432 2,3-DIHYDROXYBENZOIC ACID — 2 5.20
CHEMBL1650622 — — 2 5.12
CHEMBL220779 — — 2 4.93
CHEMBL4160929 — — 2 4.90
CHEMBL276057 — — 2 4.84
CHEMBL119083 — — 2 4.80
CHEMBL4160350 — — 2 4.72
CHEMBL79857 — — 2 4.65
CHEMBL1650630 — — 2 -
CHEMBL4171541 — — 2 -
CHEMBL4170568 — — 2 -
CHEMBL284104 DIPICOLINIC ACID — 2 -
CHEMBL46469 ANTHRALIN 2.0 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4167809 — IC50 = 8.0 nM 8.10
CHEMBL4167809 — IC50 = 7.943 nM 8.10
CHEMBL3357560 — IC50 = 10.0 nM 8.00
CHEMBL3357560 — IC50 = 11.0 nM 7.96
CHEMBL4168262 — IC50 = 37.0 nM 7.43
CHEMBL4168262 — IC50 = 39.81 nM 7.40
CHEMBL4173478 — IC50 = 39.81 nM 7.40
CHEMBL4173478 — IC50 = 43.0 nM 7.37
CHEMBL109448 — IC50 = 63.1 nM 7.20
CHEMBL109448 — IC50 = 68.0 nM 7.17
CHEMBL4168851 — IC50 = 79.43 nM 7.10
CHEMBL4168851 — IC50 = 85.0 nM 7.07
CHEMBL374569 — IC50 = 251.19 nM 6.60
CHEMBL374569 — IC50 = 260.0 nM 6.58
CHEMBL4176706 — IC50 = 398.11 nM 6.40
CHEMBL4176706 — IC50 = 420.0 nM 6.38
CHEMBL463590 — IC50 = 430.0 nM 6.37
CHEMBL4171599 — IC50 = 501.19 nM 6.30
CHEMBL4171599 — IC50 = 540.0 nM 6.27
CHEMBL4163716 — IC50 = 1200.0 nM 5.92
CHEMBL4163716 — IC50 = 1258.93 nM 5.90
CHEMBL307145 PYROGALLOL IC50 = 1584.89 nM 5.80
CHEMBL307145 PYROGALLOL IC50 = 1700.0 nM 5.77
CHEMBL4167174 — IC50 = 2511.89 nM 5.60
CHEMBL4167174 — IC50 = 2700.0 nM 5.57
CHEMBL1650617 — IC50 = 3162.28 nM 5.50
CHEMBL1650617 — IC50 = 3500.0 nM 5.46
CHEMBL4159916 — IC50 = 3800.0 nM 5.42
CHEMBL4163471 — IC50 = 3900.0 nM 5.41
CHEMBL4163471 — IC50 = 3981.07 nM 5.40
CHEMBL4159916 — IC50 = 3981.07 nM 5.40
CHEMBL288114 GALLIC ACID IC50 = 3981.07 nM 5.40
CHEMBL288114 GALLIC ACID IC50 = 4200.0 nM 5.38
CHEMBL1432 2,3-DIHYDROXYBENZOIC ACID IC50 = 6309.57 nM 5.20
CHEMBL1432 2,3-DIHYDROXYBENZOIC ACID IC50 = 6500.0 nM 5.19
CHEMBL1650622 — IC50 = 7500.0 nM 5.12
CHEMBL1650622 — IC50 = 7943.28 nM 5.10
CHEMBL220779 — IC50 = 11800.0 nM 4.93
CHEMBL220779 — IC50 = 12589.25 nM 4.90
CHEMBL4160929 — IC50 = 12589.25 nM 4.90
CHEMBL4160929 — IC50 = 13600.0 nM 4.87
CHEMBL276057 — IC50 = 14300.0 nM 4.84
CHEMBL119083 — IC50 = 15848.93 nM 4.80
CHEMBL276057 — IC50 = 15848.93 nM 4.80
CHEMBL119083 — IC50 = 17100.0 nM 4.77
CHEMBL4160350 — IC50 = 19000.0 nM 4.72
CHEMBL4160350 — IC50 = 19952.62 nM 4.70
CHEMBL79857 — IC50 = 22500.0 nM 4.65
CHEMBL79857 — IC50 = 25118.86 nM 4.60
CHEMBL4170568 — IC50 > 50118.72 nM -