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Assay Detail

CHEMBL4177775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat FAAH assessed as reduction in [14C]oleamide conversion to oleic acid by Lineweaver-Burk plot analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fatty-acid amide hydrolase 1 (CHEMBL3229)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.
Tuo W, Leleu-Chavain N, Spencer J, Sansook S, Millet R, Chavatte P.
J Med Chem (2017) 60 : 4 -46
PubMed 27766867 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 8.81 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL175854 1 9.70
CHEMBL367966 1 9.55
CHEMBL464186 1 9.52
CHEMBL179760 1 9.41
CHEMBL182199 1 9.28
CHEMBL257307 1 9.24
CHEMBL257305 1 9.16
CHEMBL1812708 1 9.12
CHEMBL35925 1 8.64
CHEMBL272770 1 8.43
CHEMBL1812590 1 8.14
CHEMBL1812591 1 7.96
CHEMBL285678 1 6.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL175854 Ki = 0.2 nM 9.70
CHEMBL367966 Ki = 0.28 nM 9.55
CHEMBL464186 Ki = 0.3 nM 9.52
CHEMBL179760 Ki = 0.39 nM 9.41
CHEMBL182199 Ki = 0.52 nM 9.28
CHEMBL257307 Ki = 0.57 nM 9.24
CHEMBL257305 Ki = 0.69 nM 9.16
CHEMBL1812708 Ki = 0.75 nM 9.12
CHEMBL35925 Ki = 2.3 nM 8.64
CHEMBL272770 Ki = 3.7 nM 8.43
CHEMBL1812590 Ki = 7.2 nM 8.14
CHEMBL1812591 Ki = 11.0 nM 7.96
CHEMBL285678 Ki = 370.0 nM 6.43