Assay Detail
Binding
CHEMBL4177820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length MAGL expressed in HEK293 cells preincubated for 30 mins followed by FP-Rh addition after 30 mins by gel-based ABPP assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.27 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356976 | — | — | 1 | 8.43 |
| CHEMBL3901007 | — | — | 1 | 8.23 |
| CHEMBL3959117 | — | — | 1 | 8.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356976 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3901007 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3959117 | — | IC50 | = | 6.9 | nM | 8.16 |