Assay Detail
Functional
CHEMBL4178185
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Antiparasitic activity against Cryptosporidium parvum Iowa oocysts infected in human HCT8 cells pretreated prior to infection measured after 48 hrs by fluorescein labeled Vicia villosa lectin/Hoechst 33258 staining based epifluorescence microscopic analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cryptosporidium parvum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.51 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205167 | — | — | 1 | 5.89 |
| CHEMBL4209540 | — | — | 1 | 5.58 |
| CHEMBL4208125 | — | — | 1 | 5.41 |
| CHEMBL264406 | — | — | 1 | 5.39 |
| CHEMBL365663 | GW780159X | — | 1 | 5.26 |
| CHEMBL4214228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205167 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4209540 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4208125 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL264406 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL365663 | GW780159X | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4214228 | — | EC50 | - | — | - |