Assay Detail
Binding
CHEMBL4178552
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Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation counting method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL2789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.68 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 6.44 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | 6.44 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.42 |
| CHEMBL4210403 | — | — | 1 | 6.11 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | — | 1 | 6.03 |
| CHEMBL4205522 | — | — | 1 | 6.01 |
| CHEMBL4206971 | — | — | 1 | 5.89 |
| CHEMBL312186 | — | — | 1 | 5.82 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.81 |
| CHEMBL601464 | — | — | 1 | 5.80 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.76 |
| CHEMBL6665 | — | — | 1 | 5.69 |
| CHEMBL589354 | — | — | 1 | 5.47 |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | 5.43 |
| CHEMBL128000 | BUTEIN | — | 1 | 5.14 |
| CHEMBL487601 | JACEOSIDINE | — | 1 | 5.03 |
| CHEMBL131921 | BIOCHANIN | — | 1 | 5.00 |
| CHEMBL9352 | NARINGENIN | — | 1 | 4.84 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 4.78 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | - |
| CHEMBL28 | APIGENIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150 | KAEMPFEROL | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4210403 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4205522 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4206971 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL312186 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL50 | QUERCETIN | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL601464 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL140 | CURCUMIN | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL6665 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL589354 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL324842 | ROSMARINIC ACID | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL128000 | BUTEIN | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL487601 | JACEOSIDINE | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL131921 | BIOCHANIN | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL9352 | NARINGENIN | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL44 | GENISTEIN | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | IC50 | > | 20000.0 | nM | - |
| CHEMBL28 | APIGENIN | IC50 | > | 20000.0 | nM | - |