Assay Detail
Binding
CHEMBL4179016
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Inhibition of JAK3 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advances in JAK3 inhibition: Isoform selectivity by covalent cysteine targeting.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.40 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4085457 | RITLECITINIB | 4.0 | 1 | 9.46 |
| CHEMBL4209692 | — | — | 1 | 9.37 |
| CHEMBL3622376 | — | — | 1 | 7.46 |
| CHEMBL4204801 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4085457 | RITLECITINIB | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL4209692 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL3622376 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4204801 | — | IC50 | = | 49.0 | nM | 7.31 |