Assay Detail
Functional
CHEMBL4179250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV2 ROD 3B infected in human MT4 cells assessed as inhibition of viral-induced cytopathic effect by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.46 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 8.42 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.96 |
| CHEMBL518520 | RALTEGRAVIR POTASSIUM | 4.0 | 1 | 7.80 |
| CHEMBL4218534 | — | — | 1 | 5.55 |
| CHEMBL4217571 | — | — | 1 | 4.84 |
| CHEMBL4215971 | — | — | 1 | 4.16 |
| CHEMBL4217679 | — | — | 1 | - |
| CHEMBL4211952 | — | — | 1 | - |
| CHEMBL4204847 | — | — | 1 | - |
| CHEMBL4209720 | — | — | 1 | - |
| CHEMBL4211903 | — | — | 1 | - |
| CHEMBL4208084 | — | — | 1 | - |
| CHEMBL4207826 | — | — | 1 | - |
| CHEMBL4213875 | — | — | 1 | - |
| CHEMBL4207034 | — | — | 1 | - |
| CHEMBL4210132 | — | — | 1 | - |
| CHEMBL4210823 | — | — | 1 | - |
| CHEMBL4211950 | — | — | 1 | - |
| CHEMBL4214520 | — | — | 1 | - |
| CHEMBL4209924 | — | — | 1 | - |
| CHEMBL4217288 | — | — | 1 | - |
| CHEMBL4212898 | — | — | 1 | - |
| CHEMBL4217053 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL518520 | RALTEGRAVIR POTASSIUM | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4218534 | — | EC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL4217571 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4215971 | — | EC50 | = | 69400.0 | nM | 4.16 |
| CHEMBL4217679 | — | EC50 | > | 21800.0 | nM | - |
| CHEMBL4211952 | — | EC50 | > | 22300.0 | nM | - |
| CHEMBL4204847 | — | EC50 | > | 22400.0 | nM | - |
| CHEMBL4209720 | — | EC50 | > | 17800.0 | nM | - |
| CHEMBL4211903 | — | EC50 | > | 24000.0 | nM | - |
| CHEMBL4208084 | — | EC50 | > | 25100.0 | nM | - |
| CHEMBL4207826 | — | EC50 | > | 239200.0 | nM | - |
| CHEMBL4213875 | — | EC50 | > | 275100.0 | nM | - |
| CHEMBL4207034 | — | EC50 | > | 264600.0 | nM | - |
| CHEMBL4210132 | — | EC50 | > | 273300.0 | nM | - |
| CHEMBL4210823 | — | EC50 | > | 239300.0 | nM | - |
| CHEMBL4211950 | — | EC50 | > | 2700.0 | nM | - |
| CHEMBL4214520 | — | EC50 | > | 1100.0 | nM | - |
| CHEMBL4209924 | — | EC50 | > | 23700.0 | nM | - |
| CHEMBL4217288 | — | EC50 | > | 24700.0 | nM | - |
| CHEMBL4212898 | — | EC50 | > | 24100.0 | nM | - |
| CHEMBL4217053 | — | EC50 | > | 24900.0 | nM | - |