Assay Detail
Binding
CHEMBL4179396
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant SIRT6 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrate and NAD+ by fluorescence based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-6 (CHEMBL2163182) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.47 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217987 | — | — | 1 | 4.70 |
| CHEMBL4205716 | — | — | 1 | 4.66 |
| CHEMBL4206619 | — | — | 1 | 4.47 |
| CHEMBL1588664 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217987 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4205716 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4206619 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1588664 | — | IC50 | = | 89000.0 | nM | 4.05 |