NAD-dependent protein deacylase sirtuin-6 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q8N6T7. Use UniProt Q8N6T7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8N6T7 as the stable identity anchor, then attach disease evidence before program review.
NAD-dependent protein deacylase sirtuin-6
Review this target as NAD-dependent protein deacylase sirtuin-6, mapped to UniProt Q8N6T7. Sequence length is 355 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NAD-dependent protein deacylase sirtuin-6 as ChEMBL target CHEMBL2163182, mapped to UniProt Q8N6T7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | NAD-dependent protein deacylase sirtuin-6 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8N6T7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NAD-dependent protein deacylase sirtuin-6 |
| UniProt Accession | Q8N6T7 |
| Component Type | Protein |
| Sequence Length | 355 aa |
NAD-dependent protein deacylase sirtuin-6
Review this target as NAD-dependent protein deacylase sirtuin-6, mapped to UniProt Q8N6T7. Sequence length is 355 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4438193 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL5277251 | 6.59 | IC50 | 256.0 | Preclinical |
| CHEMBL5274589 | 6.55 | IC50 | 282.0 | Preclinical |
| CHEMBL5281352 | 6.5 | IC50 | 319.0 | Preclinical |
| CHEMBL5267327 | 6.5 | IC50 | 319.0 | Preclinical |
| CHEMBL5280037 | 6.43 | IC50 | 368.0 | Preclinical |
| CHEMBL5270531 | 6.3 | IC50 | 495.0 | Preclinical |
| CHEMBL4645806 | 5.77 | IC50 | 1700.0 | Preclinical |
| CHEMBL151 | 5.72 | IC50 | 1900.0 | Clinical |
| CHEMBL50 | 5.72 | IC50 | 1900.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 108 | 77 | 4.9 |
| cell-based format | 46 | 1 | 5.2 |
| assay format | 38 | 18 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 2 | 0 | — |