Compound Detail
CHEMBL5280037
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CCCCCCCCCCCNC(=S)NCCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(C)=O)CCCCNC(=O)CNC(=O)CCCCCCC(=O)NCC(=O)NCCCC[C@@H](C(=O)N[C@H](C(=O)O)[C@@H](C)O)NC1=O
Basic Information
| ChEMBL ID | CHEMBL5280037 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SXVVITZGBMYLDO-MBDYEZFZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1167.5
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NAD-dependent protein deacylase sirtuin-6 CHEMBL2163182 | IC50 | 6.43 | 6.43 | 368.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NAD-dependent protein deacylase sirtuin-6 | IC50 | = | 368.0 | nM | 6.43 | Inhibition of SIRT6 (unknown origin) | 34213345 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34213345 | 10.1021/acs.jmedchem.1c00601 | NAD-dependent protein deacylase sirtuin-6 | 1 |
Data from ChEMBL 36 via Core Engine