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Assay Detail

CHEMBL5227969

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of SIRT6 (unknown origin)
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

NAD-dependent protein deacylase sirtuin-6 (CHEMBL2163182)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Emerging Therapeutic Potential of SIRT6 Modulators.
Fiorentino F, Mai A, Rotili D.
J Med Chem (2021) 64 : 9732 -9758
PubMed 34213345 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.76 6.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5277251 1 6.59
CHEMBL5274589 1 6.55
CHEMBL5281352 2 6.50
CHEMBL5267327 1 6.50
CHEMBL5280037 1 6.43
CHEMBL5270531 1 6.30
CHEMBL4205716 1 4.66
CHEMBL222382 1 4.48
CHEMBL4206619 1 4.47
CHEMBL4208668 1 4.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5277251 IC50 = 256.0 nM 6.59
CHEMBL5274589 IC50 = 282.0 nM 6.55
CHEMBL5281352 IC50 = 319.0 nM 6.50
CHEMBL5281352 IC50 = 319.0 nM 6.50
CHEMBL5267327 IC50 = 319.0 nM 6.50
CHEMBL5280037 IC50 = 368.0 nM 6.43
CHEMBL5270531 IC50 = 495.0 nM 6.30
CHEMBL4205716 IC50 = 22000.0 nM 4.66
CHEMBL222382 IC50 = 33200.0 nM 4.48
CHEMBL4206619 IC50 = 34000.0 nM 4.47
CHEMBL4208668 IC50 = 40400.0 nM 4.39