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Assay Detail

CHEMBL4179600

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells after 2 days by CellTiter-Glo luminescent cell viability assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Intermediate

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
Papadopoulou MV, Bloomer WD, Rosenzweig HS.
Bioorg Med Chem (2017) 25 : 6039 -6048
PubMed 28993106 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.37 4.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4217594 1 4.77
CHEMBL4209908 1 4.64
CHEMBL3612338 1 4.54
CHEMBL4206147 1 4.50
CHEMBL3633322 1 4.50
CHEMBL3612343 1 4.44
CHEMBL4213380 1 4.44
CHEMBL4202551 1 4.40
CHEMBL3612341 1 4.35
CHEMBL3633321 1 4.22
CHEMBL3612346 1 4.20
CHEMBL4208967 1 4.07
CHEMBL3410623 1 4.06
CHEMBL3612337 1 4.04
CHEMBL3410626 1 -
CHEMBL3358487 1 -
CHEMBL3612347 1 -
CHEMBL3612837 1 -
CHEMBL3633320 1 -
CHEMBL3358488 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4217594 IC50 = 17000.0 nM 4.77
CHEMBL4209908 IC50 = 23000.0 nM 4.64
CHEMBL3612338 IC50 = 29000.0 nM 4.54
CHEMBL4206147 IC50 = 32000.0 nM 4.50
CHEMBL3633322 IC50 = 32000.0 nM 4.50
CHEMBL3612343 IC50 = 36000.0 nM 4.44
CHEMBL4213380 IC50 = 36000.0 nM 4.44
CHEMBL4202551 IC50 = 40000.0 nM 4.40
CHEMBL3612341 IC50 = 45000.0 nM 4.35
CHEMBL3633321 IC50 = 60000.0 nM 4.22
CHEMBL3612346 IC50 = 63000.0 nM 4.20
CHEMBL4208967 IC50 = 86000.0 nM 4.07
CHEMBL3410623 IC50 = 88000.0 nM 4.06
CHEMBL3612337 IC50 = 92000.0 nM 4.04
CHEMBL3410626 IC50 = 103000.0 nM -
CHEMBL3358487 IC50 > 264000.0 nM -
CHEMBL3612347 IC50 = 127000.0 nM -
CHEMBL3612837 IC50 = 123000.0 nM -
CHEMBL3633320 IC50 = 111000.0 nM -
CHEMBL3358488 IC50 = 154000.0 nM -