Assay Detail
Functional
CHEMBL4179604
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Antitubercular activity against luxABCDE expressing Mycobacterium tuberculosis H37Rv infected in human THP1 cells measured after 3 days by luminescence assay
24
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.41 | 6.72 |
| IC90 | 12 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64 | ISONIAZID | 4.0 | 2 | 6.72 |
| CHEMBL4202551 | — | — | 2 | 5.89 |
| CHEMBL4213380 | — | — | 2 | 5.64 |
| CHEMBL4217594 | — | — | 2 | 5.47 |
| CHEMBL4209908 | — | — | 2 | 5.42 |
| CHEMBL3633321 | — | — | 2 | 5.40 |
| CHEMBL4206147 | — | — | 2 | 5.30 |
| CHEMBL3612343 | — | — | 2 | 5.21 |
| CHEMBL3633322 | — | — | 2 | 5.10 |
| CHEMBL3612341 | — | — | 2 | 4.96 |
| CHEMBL3410626 | — | — | 2 | 4.96 |
| CHEMBL3633320 | — | — | 2 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64 | ISONIAZID | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4202551 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4213380 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4217594 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4209908 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3633321 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4206147 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3612343 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3633322 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3612341 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3410626 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3633320 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3612343 | — | IC90 | = | 12000.0 | nM | - |
| CHEMBL3612341 | — | IC90 | = | 12000.0 | nM | - |
| CHEMBL3410626 | — | IC90 | = | 25000.0 | nM | - |
| CHEMBL4217594 | — | IC90 | = | 10000.0 | nM | - |
| CHEMBL4206147 | — | IC90 | = | 17000.0 | nM | - |
| CHEMBL4209908 | — | IC90 | = | 16000.0 | nM | - |
| CHEMBL4202551 | — | IC90 | = | 2900.0 | nM | - |
| CHEMBL4213380 | — | IC90 | = | 4100.0 | nM | - |
| CHEMBL3633320 | — | IC90 | = | 14000.0 | nM | - |
| CHEMBL3633321 | — | IC90 | = | 6700.0 | nM | - |
| CHEMBL3633322 | — | IC90 | = | 11000.0 | nM | - |
| CHEMBL64 | ISONIAZID | IC90 | = | 240.0 | nM | - |