Assay Detail
Binding
CHEMBL4180642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALR1 in Wistar rat kidney assessed as reduction in NADPH consumption preincubated for 1 min followed by substrate addition measured after 4 mins by spectrophotometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.82 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4219003 | — | — | 1 | 5.32 |
| CHEMBL4216153 | — | — | 1 | 5.12 |
| CHEMBL4206601 | — | — | 1 | 5.00 |
| CHEMBL4207775 | — | — | 1 | 4.95 |
| CHEMBL1897400 | — | — | 1 | 4.93 |
| CHEMBL2391535 | — | — | 1 | 4.66 |
| CHEMBL4207499 | — | — | 1 | 4.36 |
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | 4.25 |
| CHEMBL4202616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4219003 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL4216153 | — | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL4206601 | — | IC50 | = | 9980.0 | nM | 5.00 |
| CHEMBL4207775 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1897400 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL2391535 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL4207499 | — | IC50 | = | 43800.0 | nM | 4.36 |
| CHEMBL109 | VALPROIC ACID | IC50 | = | 56100.0 | nM | 4.25 |
| CHEMBL4202616 | — | IC50 | > | 100000.0 | nM | - |