Assay Detail
Binding
CHEMBL4180913
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Inhibition of rat brain AChE using acetylthiocholine iodide as substrate by spectroscopic method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of multi-target potential of chromen-4-one based compounds in Alzheimer's disease: Design, synthesis and biological evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.74 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217941 | — | — | 1 | 8.23 |
| CHEMBL4207594 | — | — | 1 | 8.21 |
| CHEMBL4208825 | — | — | 1 | 8.19 |
| CHEMBL4213552 | — | — | 1 | 8.17 |
| CHEMBL4214058 | — | — | 1 | 8.11 |
| CHEMBL4204793 | — | — | 1 | 8.08 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.90 |
| CHEMBL4209658 | — | — | 1 | 7.87 |
| CHEMBL4207152 | — | — | 1 | 7.81 |
| CHEMBL4218884 | — | — | 1 | 7.78 |
| CHEMBL4210581 | — | — | 1 | 7.76 |
| CHEMBL16751 | — | — | 1 | 7.46 |
| CHEMBL345778 | — | — | 1 | 7.43 |
| CHEMBL485247 | — | — | 1 | 7.36 |
| CHEMBL4205720 | — | — | 1 | 7.32 |
| CHEMBL4216881 | — | — | 1 | 7.24 |
| CHEMBL4203490 | — | — | 1 | 7.18 |
| CHEMBL4218485 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217941 | — | IC50 | = | 5.87 | nM | 8.23 |
| CHEMBL4207594 | — | IC50 | = | 6.12 | nM | 8.21 |
| CHEMBL4208825 | — | IC50 | = | 6.48 | nM | 8.19 |
| CHEMBL4213552 | — | IC50 | = | 6.77 | nM | 8.17 |
| CHEMBL4214058 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4204793 | — | IC50 | = | 8.25 | nM | 8.08 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL4209658 | — | IC50 | = | 13.53 | nM | 7.87 |
| CHEMBL4207152 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL4218884 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL4210581 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL16751 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL345778 | — | IC50 | = | 37.3 | nM | 7.43 |
| CHEMBL485247 | — | IC50 | = | 44.2 | nM | 7.36 |
| CHEMBL4205720 | — | IC50 | = | 48.12 | nM | 7.32 |
| CHEMBL4216881 | — | IC50 | = | 57.2 | nM | 7.24 |
| CHEMBL4203490 | — | IC50 | = | 65.7 | nM | 7.18 |
| CHEMBL4218485 | — | IC50 | = | 67.2 | nM | 7.17 |