Assay Detail
Functional
CHEMBL4181455
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 10.11 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205723 | — | — | 1 | 10.80 |
| CHEMBL4217429 | — | — | 1 | 10.20 |
| CHEMBL4217945 | — | — | 1 | 9.89 |
| CHEMBL4218141 | — | — | 1 | 9.87 |
| CHEMBL4209576 | — | — | 1 | 9.78 |
| CHEMBL4213013 | — | — | 1 | - |
| CHEMBL4214485 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205723 | — | IC50 | = | 0.016 | nM | 10.80 |
| CHEMBL4217429 | — | IC50 | = | 0.063 | nM | 10.20 |
| CHEMBL4217945 | — | IC50 | = | 0.129 | nM | 9.89 |
| CHEMBL4218141 | — | IC50 | = | 0.135 | nM | 9.87 |
| CHEMBL4209576 | — | IC50 | = | 0.167 | nM | 9.78 |
| CHEMBL4213013 | — | IC50 | = | 0.006 | nM | - |
| CHEMBL4214485 | — | IC50 | - | — | - |