Assay Detail
Functional
CHEMBL4181497
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Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and anticancer properties of isocorydine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.53 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4202902 | — | — | 1 | 5.12 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 4.82 |
| CHEMBL4208716 | — | — | 1 | 4.79 |
| CHEMBL4216060 | — | — | 1 | 4.76 |
| CHEMBL4217441 | — | — | 1 | 4.76 |
| CHEMBL4207789 | — | — | 1 | 4.72 |
| CHEMBL4205367 | — | — | 1 | 4.68 |
| CHEMBL4218911 | — | — | 1 | 4.67 |
| CHEMBL4216509 | — | — | 1 | 4.59 |
| CHEMBL4207253 | — | — | 1 | 4.57 |
| CHEMBL4205736 | — | — | 1 | 4.55 |
| CHEMBL4209748 | — | — | 1 | 4.54 |
| CHEMBL4214661 | — | — | 1 | 4.54 |
| CHEMBL4215442 | — | — | 1 | 4.52 |
| CHEMBL4216583 | — | — | 1 | 4.50 |
| CHEMBL4215674 | — | — | 1 | 4.43 |
| CHEMBL4203217 | — | — | 1 | 4.40 |
| CHEMBL4212136 | — | — | 1 | 4.36 |
| CHEMBL4207320 | — | — | 1 | 4.34 |
| CHEMBL4203997 | — | — | 1 | 4.29 |
| CHEMBL4203839 | — | — | 1 | 4.27 |
| CHEMBL4210501 | — | — | 1 | 4.20 |
| CHEMBL4206143 | — | — | 1 | 4.16 |
| CHEMBL4211030 | — | — | 1 | 4.12 |
| CHEMBL489525 | ISOCORYDINE | — | 1 | - |
| CHEMBL4215176 | — | — | 1 | - |
| CHEMBL227965 | CORYTUBERINE | — | 1 | - |
| CHEMBL489524 | CORYDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4202902 | — | IC50 | = | 7510.0 | nM | 5.12 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4208716 | — | IC50 | = | 16150.0 | nM | 4.79 |
| CHEMBL4216060 | — | IC50 | = | 17250.0 | nM | 4.76 |
| CHEMBL4217441 | — | IC50 | = | 17160.0 | nM | 4.76 |
| CHEMBL4207789 | — | IC50 | = | 18940.0 | nM | 4.72 |
| CHEMBL4205367 | — | IC50 | = | 20690.0 | nM | 4.68 |
| CHEMBL4218911 | — | IC50 | = | 21530.0 | nM | 4.67 |
| CHEMBL4216509 | — | IC50 | = | 25910.0 | nM | 4.59 |
| CHEMBL4207253 | — | IC50 | = | 26670.0 | nM | 4.57 |
| CHEMBL4205736 | — | IC50 | = | 28360.0 | nM | 4.55 |
| CHEMBL4209748 | — | IC50 | = | 28610.0 | nM | 4.54 |
| CHEMBL4214661 | — | IC50 | = | 28520.0 | nM | 4.54 |
| CHEMBL4215442 | — | IC50 | = | 30190.0 | nM | 4.52 |
| CHEMBL4216583 | — | IC50 | = | 31350.0 | nM | 4.50 |
| CHEMBL4215674 | — | IC50 | = | 36740.0 | nM | 4.43 |
| CHEMBL4203217 | — | IC50 | = | 40020.0 | nM | 4.40 |
| CHEMBL4212136 | — | IC50 | = | 44110.0 | nM | 4.36 |
| CHEMBL4207320 | — | IC50 | = | 45860.0 | nM | 4.34 |
| CHEMBL4203997 | — | IC50 | = | 51120.0 | nM | 4.29 |
| CHEMBL4203839 | — | IC50 | = | 53170.0 | nM | 4.27 |
| CHEMBL4210501 | — | IC50 | = | 63370.0 | nM | 4.20 |
| CHEMBL4206143 | — | IC50 | = | 69750.0 | nM | 4.16 |
| CHEMBL4211030 | — | IC50 | = | 75370.0 | nM | 4.12 |
| CHEMBL489525 | ISOCORYDINE | IC50 | > | 200000.0 | nM | - |
| CHEMBL4215176 | — | IC50 | = | 153900.0 | nM | - |
| CHEMBL227965 | CORYTUBERINE | IC50 | > | 200000.0 | nM | - |
| CHEMBL489524 | CORYDINE | IC50 | > | 200000.0 | nM | - |