Compound Detail
CHEMBL489524
CORYDINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL489524 |
| Name | CORYDINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IDQUPXZJURZAGF-ZDUSSCGKSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
341.4
MW (Da)
3.17
ALogP
5
HBA
1
HBD
51.2
PSA (Ų)
0.93
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.65
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 4.65 | 4.65 | 22300.0 | 1 |
| Entamoeba histolytica CHEMBL612853 | IC50 | 4.04 | 4.04 | 90600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 22300.0 | nM | 4.65 | Antiplasmodial activity against multi drug-resistant Plasmodium falciparum K1 in... | 11141105 |
| Entamoeba histolytica | IC50 | = | 90600.0 | nM | 4.04 | Antiamnesic activity against Entamoeba histolytica NIH 200 after 72 hrs by micro... | 11141105 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8254346 | 10.1021/np50099a005 | Plasmodium falciparum | 2 |
| - | 10.6019/CHEMBL4888484 | Plasmodium falciparum | 2 |
| 11141105 | 10.1021/np000144r | Plasmodium falciparum | 1 |
| 11141105 | 10.1021/np000144r | Entamoeba histolytica | 1 |
| 11141105 | 10.1021/np000144r | KB | 1 |
| 20097066 | 10.1016/j.bmcl.2010.01.007 | Cyclin-dependent kinase 2 | 1 |
| - | 10.1007/s00044-011-9767-1 | Entamoeba histolytica | 1 |
| 29103873 | 10.1016/j.bmc.2017.10.027 | HepG2 | 1 |
| 29103873 | 10.1016/j.bmc.2017.10.027 | HeLa | 1 |
| 29103873 | 10.1016/j.bmc.2017.10.027 | MGC-803 | 1 |
Data from ChEMBL 36 via Core Engine