Assay Detail
Functional
CHEMBL968123
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Antiplasmodial activity against multi drug-resistant Plasmodium falciparum K1 in erythrocytes by [3H]hypoxanthine uptake
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.24 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 6.70 |
| CHEMBL490509 | DEHYDRODISCRETINE CHLORIDE | — | 1 | 6.19 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | 6.01 |
| CHEMBL491511 | COLUMBAMINE CHLORIDE | — | 1 | 5.72 |
| CHEMBL494053 | NORCORYDINE | — | 1 | 5.51 |
| CHEMBL274346 | JATRORRHIZINE CHLORIDE | — | 1 | 5.50 |
| CHEMBL520043 | ALLOCRYPTOPINE | — | 1 | 5.29 |
| CHEMBL522429 | DEHYDROOCOTEINE | — | 1 | 5.24 |
| CHEMBL492162 | USHINSUNINE | — | 1 | 5.22 |
| CHEMBL491544 | THALIFENDINE | — | 1 | 5.10 |
| CHEMBL450614 | THALICMININE | — | 1 | 4.79 |
| CHEMBL489524 | CORYDINE | — | 1 | 4.65 |
| CHEMBL486380 | CATALPIFOLINE | — | 1 | 4.62 |
| CHEMBL486179 | PROTOPINE | — | 1 | 4.47 |
| CHEMBL443099 | OCOTEINE | — | 1 | 4.46 |
| CHEMBL489525 | ISOCORYDINE | — | 1 | 4.43 |
| CHEMBL248095 | SINOMENINE | 3.0 | 1 | - |
| CHEMBL404097 | SALUTARIDINE | — | 1 | - |
| CHEMBL490139 | O-METHYLFLAVINANTINE | — | 1 | - |
| CHEMBL492163 | METAPHANINE HYDROBROMIDE | — | 1 | - |
| CHEMBL490533 | CANADINE | — | 1 | - |
| CHEMBL493439 | EMETINE HYDROCHLORIDE | 2.0 | 1 | - |
| CHEMBL494052 | MAGNOFLORINE IODIDE | — | 1 | - |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL490509 | DEHYDRODISCRETINE CHLORIDE | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | = | 968.0 | nM | 6.01 |
| CHEMBL491511 | COLUMBAMINE CHLORIDE | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL494053 | NORCORYDINE | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL274346 | JATRORRHIZINE CHLORIDE | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL520043 | ALLOCRYPTOPINE | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL522429 | DEHYDROOCOTEINE | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL492162 | USHINSUNINE | IC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL491544 | THALIFENDINE | IC50 | = | 7910.0 | nM | 5.10 |
| CHEMBL450614 | THALICMININE | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL489524 | CORYDINE | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL486380 | CATALPIFOLINE | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL486179 | PROTOPINE | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL443099 | OCOTEINE | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL489525 | ISOCORYDINE | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL248095 | SINOMENINE | IC50 | > | 152000.0 | nM | - |
| CHEMBL404097 | SALUTARIDINE | IC50 | > | 95000.0 | nM | - |
| CHEMBL490139 | O-METHYLFLAVINANTINE | IC50 | = | 207000.0 | nM | - |
| CHEMBL492163 | METAPHANINE HYDROBROMIDE | IC50 | > | 117000.0 | nM | - |
| CHEMBL490533 | CANADINE | IC50 | > | 147000.0 | nM | - |
| CHEMBL493439 | EMETINE HYDROCHLORIDE | IC50 | - | — | - | |
| CHEMBL494052 | MAGNOFLORINE IODIDE | IC50 | > | 107000.0 | nM | - |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - |