Assay Detail
Functional
CHEMBL968124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiamnesic activity against Entamoeba histolytica NIH 200 after 72 hrs by microdilution technique
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.28 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493439 | EMETINE HYDROCHLORIDE | 2.0 | 1 | 5.65 |
| CHEMBL443099 | OCOTEINE | — | 1 | 4.29 |
| CHEMBL248095 | SINOMENINE | 3.0 | 1 | 4.25 |
| CHEMBL492163 | METAPHANINE HYDROBROMIDE | — | 1 | 4.23 |
| CHEMBL490509 | DEHYDRODISCRETINE CHLORIDE | — | 1 | 4.17 |
| CHEMBL486179 | PROTOPINE | — | 1 | 4.15 |
| CHEMBL490139 | O-METHYLFLAVINANTINE | — | 1 | 4.13 |
| CHEMBL404097 | SALUTARIDINE | — | 1 | 4.12 |
| CHEMBL494053 | NORCORYDINE | — | 1 | 4.12 |
| CHEMBL450614 | THALICMININE | — | 1 | 4.12 |
| CHEMBL274346 | JATRORRHIZINE CHLORIDE | — | 1 | 4.08 |
| CHEMBL489524 | CORYDINE | — | 1 | 4.04 |
| CHEMBL486380 | CATALPIFOLINE | — | 1 | - |
| CHEMBL522429 | DEHYDROOCOTEINE | — | 1 | - |
| CHEMBL489525 | ISOCORYDINE | — | 1 | - |
| CHEMBL494052 | MAGNOFLORINE IODIDE | — | 1 | - |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | - |
| CHEMBL492162 | USHINSUNINE | — | 1 | - |
| CHEMBL490533 | CANADINE | — | 1 | - |
| CHEMBL520043 | ALLOCRYPTOPINE | — | 1 | - |
| CHEMBL491544 | THALIFENDINE | — | 1 | - |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | - |
| CHEMBL491511 | COLUMBAMINE CHLORIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493439 | EMETINE HYDROCHLORIDE | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL443099 | OCOTEINE | IC50 | = | 51200.0 | nM | 4.29 |
| CHEMBL248095 | SINOMENINE | IC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL492163 | METAPHANINE HYDROBROMIDE | IC50 | = | 58600.0 | nM | 4.23 |
| CHEMBL490509 | DEHYDRODISCRETINE CHLORIDE | IC50 | = | 66900.0 | nM | 4.17 |
| CHEMBL486179 | PROTOPINE | IC50 | = | 70700.0 | nM | 4.15 |
| CHEMBL490139 | O-METHYLFLAVINANTINE | IC50 | = | 73400.0 | nM | 4.13 |
| CHEMBL404097 | SALUTARIDINE | IC50 | = | 76400.0 | nM | 4.12 |
| CHEMBL494053 | NORCORYDINE | IC50 | = | 76400.0 | nM | 4.12 |
| CHEMBL450614 | THALICMININE | IC50 | = | 75100.0 | nM | 4.12 |
| CHEMBL274346 | JATRORRHIZINE CHLORIDE | IC50 | = | 82700.0 | nM | 4.08 |
| CHEMBL489524 | CORYDINE | IC50 | = | 90600.0 | nM | 4.04 |
| CHEMBL486380 | CATALPIFOLINE | IC50 | = | 147000.0 | nM | - |
| CHEMBL522429 | DEHYDROOCOTEINE | IC50 | = | 136000.0 | nM | - |
| CHEMBL489525 | ISOCORYDINE | IC50 | > | 147000.0 | nM | - |
| CHEMBL494052 | MAGNOFLORINE IODIDE | IC50 | = | 111000.0 | nM | - |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - | |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | - | — | - | |
| CHEMBL492162 | USHINSUNINE | IC50 | - | — | - | |
| CHEMBL490533 | CANADINE | IC50 | = | 126000.0 | nM | - |
| CHEMBL520043 | ALLOCRYPTOPINE | IC50 | = | 135000.0 | nM | - |
| CHEMBL491544 | THALIFENDINE | IC50 | = | 116000.0 | nM | - |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | = | 111000.0 | nM | - |
| CHEMBL491511 | COLUMBAMINE CHLORIDE | IC50 | = | 156000.0 | nM | - |