Assay Detail
Binding
CHEMBL4181956
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Inhibition of recombinant human CYP1A1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substrate addition measured for 60 mins by fluorescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.46 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4218749 | — | — | 1 | 7.24 |
| CHEMBL4205073 | — | — | 1 | 7.20 |
| CHEMBL4210137 | — | — | 1 | 7.19 |
| CHEMBL4211876 | — | — | 1 | 7.04 |
| CHEMBL4214111 | — | — | 1 | 6.66 |
| CHEMBL4213815 | — | — | 1 | 6.55 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 6.42 |
| CHEMBL4202990 | — | — | 1 | 6.38 |
| CHEMBL1568243 | — | — | 1 | 6.26 |
| CHEMBL4209004 | — | — | 1 | 6.21 |
| CHEMBL4212722 | — | — | 1 | 6.21 |
| CHEMBL4210776 | — | — | 1 | 5.95 |
| CHEMBL2237710 | — | — | 1 | 5.88 |
| CHEMBL2237704 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4218749 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4205073 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4210137 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4211876 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4214111 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4213815 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4202990 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1568243 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4209004 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4212722 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4210776 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL2237710 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL2237704 | — | IC50 | = | 6610.0 | nM | 5.18 |