Assay Detail
Binding
CHEMBL4181977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CYP1A1 expressed in HEK293 cells assessed as reduction in benzo(a)pyrene-induced toxicity by measuring B[a]P EC50 at 2 times IC50 by MTT assay (Rvb = 0.8 +/- 0.14 uM)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.85 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205073 | — | — | 1 | 4.85 |
| CHEMBL4218749 | — | — | 1 | 4.85 |
| CHEMBL4210137 | — | — | 1 | 4.85 |
| CHEMBL4211876 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205073 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4218749 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4210137 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4211876 | — | EC50 | = | 14000.0 | nM | 4.85 |