Assay Detail
Functional
CHEMBL4181987
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Cytotoxicity against human U87MG cells assessed as reduction in cell viability after 46 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Imidazo[1,2-a]pyridines linked with thiazoles/thiophene motif through keto spacer as potential cytotoxic agents and NF-κB inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.50 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.00 |
| CHEMBL4205768 | — | — | 1 | 4.37 |
| CHEMBL4213059 | — | — | 1 | 4.35 |
| CHEMBL4214832 | — | — | 1 | 4.31 |
| CHEMBL4203396 | — | — | 1 | 4.28 |
| CHEMBL4207217 | — | — | 1 | 4.12 |
| CHEMBL4212097 | — | — | 1 | 4.09 |
| CHEMBL4203183 | — | — | 1 | - |
| CHEMBL4211571 | — | — | 1 | - |
| CHEMBL4204226 | — | — | 1 | - |
| CHEMBL4215065 | — | — | 1 | - |
| CHEMBL4202872 | — | — | 1 | - |
| CHEMBL4206279 | — | — | 1 | - |
| CHEMBL4211161 | — | — | 1 | - |
| CHEMBL4217984 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4205768 | — | IC50 | = | 43150.0 | nM | 4.37 |
| CHEMBL4213059 | — | IC50 | = | 44770.0 | nM | 4.35 |
| CHEMBL4214832 | — | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL4203396 | — | IC50 | = | 52040.0 | nM | 4.28 |
| CHEMBL4207217 | — | IC50 | = | 76480.0 | nM | 4.12 |
| CHEMBL4212097 | — | IC50 | = | 81070.0 | nM | 4.09 |
| CHEMBL4203183 | — | IC50 | - | — | - | |
| CHEMBL4211571 | — | IC50 | - | — | - | |
| CHEMBL4204226 | — | IC50 | - | — | - | |
| CHEMBL4215065 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4202872 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4206279 | — | IC50 | - | — | - | |
| CHEMBL4211161 | — | IC50 | - | — | - | |
| CHEMBL4217984 | — | IC50 | - | — | - |