Assay Detail
Binding
CHEMBL4182005
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antidepressant activity of a series of arylalkanol and aralkyl piperazine derivatives targeting SSRI/5-HT1A/5-HT7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.48 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4209430 | — | — | 1 | 9.08 |
| CHEMBL4203932 | — | — | 1 | 8.62 |
| CHEMBL4215605 | — | — | 1 | 8.20 |
| CHEMBL2104993 | VORTIOXETINE | 4.0 | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4209430 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL4203932 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL4215605 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL2104993 | VORTIOXETINE | Ki | = | 9.5 | nM | 8.02 |