Assay Detail
Functional
CHEMBL4182341
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei 427 bloodstream forms
34
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.65 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480726 | — | — | 1 | 7.52 |
| CHEMBL4218022 | — | — | 2 | 7.52 |
| CHEMBL481740 | — | — | 1 | 7.01 |
| CHEMBL4217401 | — | — | 1 | 6.85 |
| CHEMBL480569 | — | — | 2 | 6.57 |
| CHEMBL480727 | — | — | 1 | 5.96 |
| CHEMBL4211049 | — | — | 2 | 5.92 |
| CHEMBL480728 | — | — | 1 | 5.85 |
| CHEMBL4203611 | — | — | 2 | 5.80 |
| CHEMBL4216414 | — | — | 1 | 5.37 |
| CHEMBL4204439 | — | — | 1 | 5.25 |
| CHEMBL4216446 | — | — | 1 | 4.82 |
| CHEMBL4215751 | — | — | 1 | 4.80 |
| CHEMBL4208438 | — | — | 1 | 4.72 |
| CHEMBL4206242 | — | — | 1 | 4.47 |
| CHEMBL4212632 | — | — | 1 | 4.40 |
| CHEMBL480559 | — | — | 1 | 4.36 |
| CHEMBL4211008 | — | — | 1 | - |
| CHEMBL480196 | — | — | 1 | - |
| CHEMBL1836597 | — | — | 1 | - |
| CHEMBL4203482 | — | — | 1 | - |
| CHEMBL4209260 | — | — | 1 | - |
| CHEMBL3608950 | — | — | 1 | - |
| CHEMBL489293 | — | — | 1 | - |
| CHEMBL1836445 | — | — | 1 | - |
| CHEMBL4211261 | — | — | 1 | - |
| CHEMBL3608951 | — | — | 1 | - |
| CHEMBL4207256 | — | — | 1 | - |
| CHEMBL4202539 | — | — | 1 | - |
| CHEMBL2347704 | ACOZIBOROLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4218022 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL480726 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4218022 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL481740 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4217401 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL480569 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL480727 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4211049 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL480728 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4203611 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4216414 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4204439 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL480569 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4216446 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4215751 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4211049 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4208438 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4206242 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4212632 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL480559 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL4203611 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL4211008 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL480196 | — | IC50 | = | 3.0 | ug.mL-1 | - |
| CHEMBL1836597 | — | IC50 | = | 2.8 | ug.mL-1 | - |
| CHEMBL4203482 | — | IC50 | = | 2.7 | ug.mL-1 | - |
| CHEMBL4209260 | — | IC50 | = | 2.2 | ug.mL-1 | - |
| CHEMBL3608950 | — | IC50 | = | 0.83 | ug.mL-1 | - |
| CHEMBL489293 | — | IC50 | = | 0.78 | ug.mL-1 | - |
| CHEMBL1836445 | — | IC50 | = | 0.53 | ug.mL-1 | - |
| CHEMBL4211261 | — | IC50 | = | 0.46 | ug.mL-1 | - |
| CHEMBL3608951 | — | IC50 | = | 0.28 | ug.mL-1 | - |
| CHEMBL4207256 | — | IC50 | = | 0.23 | ug.mL-1 | - |
| CHEMBL4202539 | — | IC50 | = | 0.13 | ug.mL-1 | - |
| CHEMBL2347704 | ACOZIBOROLE | IC50 | = | 0.29 | ug.mL-1 | - |