Assay Detail
Binding
CHEMBL4182607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SYK (unknown origin) using FITC-labeled Blk/Lyntide substrate and ATP by microfluidic mobility shift assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel pyrimidine analogs as highly selective, non-covalent BTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.44 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217692 | — | — | 1 | 6.44 |
| CHEMBL4203409 | — | — | 1 | - |
| CHEMBL4211270 | — | — | 1 | - |
| CHEMBL4208579 | — | — | 1 | - |
| CHEMBL4212308 | — | — | 1 | - |
| CHEMBL4205977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217692 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4203409 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4211270 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4208579 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4212308 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4205977 | — | IC50 | > | 10000.0 | nM | - |