Assay Detail
Binding
CHEMBL4182928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NDM1 in Escherichia coli BL21 (DE3) using MEPM substrate incubated for 15 mins by UV spectroscopy
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
NOTA analogue: A first dithiocarbamate inhibitor of metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.11 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2005280 | — | — | 1 | 6.96 |
| CHEMBL4212352 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2005280 | — | IC50 | = | 109.5 | nM | 6.96 |
| CHEMBL4212352 | — | IC50 | = | 5624.0 | nM | 5.25 |