Assay Detail
Binding
CHEMBL4182983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-ifenprodil from recombinant human GluN1a/GluN2B expressed in L(tk-) cell membranes after 120 mins by scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.31 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 8.00 |
| CHEMBL1289626 | — | — | 1 | 7.85 |
| CHEMBL4206913 | — | — | 1 | 7.77 |
| CHEMBL4218465 | — | — | 1 | 7.25 |
| CHEMBL3753409 | — | — | 1 | 7.14 |
| CHEMBL4204621 | — | — | 1 | 6.60 |
| CHEMBL4205955 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305187 | IFENPRODIL | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1289626 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4206913 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4218465 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL3753409 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL4204621 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL4205955 | — | Ki | = | 259.0 | nM | 6.59 |