Assay Detail
Binding
CHEMBL4183544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from muscarinic receptor in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.97 | 8.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4215958 | — | — | 1 | 8.53 |
| CHEMBL4216478 | — | — | 1 | 8.49 |
| CHEMBL1382 | TOLTERODINE | 4.0 | 1 | 8.20 |
| CHEMBL4204282 | — | — | 1 | 8.15 |
| CHEMBL4211510 | — | — | 1 | 7.88 |
| CHEMBL4206276 | — | — | 1 | 7.86 |
| CHEMBL4208614 | — | — | 1 | 7.74 |
| CHEMBL4207504 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4215958 | — | IC50 | = | 2.951 | nM | 8.53 |
| CHEMBL4216478 | — | IC50 | = | 3.236 | nM | 8.49 |
| CHEMBL1382 | TOLTERODINE | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4204282 | — | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL4211510 | — | IC50 | = | 13.18 | nM | 7.88 |
| CHEMBL4206276 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL4208614 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL4207504 | — | IC50 | = | 123.03 | nM | 6.91 |