Assay Detail
Binding
CHEMBL4184342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length His-tagged CaMK2delta expressed in baculovirus using Biotin labelled STK1 as substrate after 1 hr in presence of ATP by fluorescence assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase type II subunit delta (CHEMBL2801) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 8.31 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4218769 | — | — | 1 | 10.30 |
| CHEMBL4208018 | — | — | 1 | 10.22 |
| CHEMBL4215817 | — | — | 1 | 10.15 |
| CHEMBL4218245 | — | — | 1 | 10.10 |
| CHEMBL4217261 | — | — | 1 | 10.05 |
| CHEMBL4210359 | — | — | 1 | 10.00 |
| CHEMBL4215300 | — | — | 1 | 10.00 |
| CHEMBL4206514 | — | — | 1 | 10.00 |
| CHEMBL4209816 | — | — | 1 | 9.66 |
| CHEMBL4213838 | — | — | 1 | 9.64 |
| CHEMBL4210881 | — | — | 1 | 9.55 |
| CHEMBL4205997 | — | — | 1 | 9.52 |
| CHEMBL4209443 | — | — | 1 | 9.04 |
| CHEMBL4205708 | — | — | 1 | 8.80 |
| CHEMBL4211430 | — | — | 1 | 8.66 |
| CHEMBL4213305 | — | — | 1 | 8.48 |
| CHEMBL4209840 | — | — | 1 | 8.47 |
| CHEMBL4210568 | — | — | 1 | 8.46 |
| CHEMBL4208717 | — | — | 1 | 8.40 |
| CHEMBL4216080 | — | — | 1 | 8.24 |
| CHEMBL4213540 | — | — | 1 | 8.14 |
| CHEMBL4214345 | — | — | 1 | 8.04 |
| CHEMBL4215541 | — | — | 1 | 7.43 |
| CHEMBL4211934 | — | — | 1 | 7.39 |
| CHEMBL4210073 | — | — | 1 | 7.36 |
| CHEMBL4209789 | — | — | 1 | 7.28 |
| CHEMBL4205405 | — | — | 1 | 7.24 |
| CHEMBL4209139 | — | — | 1 | 7.19 |
| CHEMBL4204410 | — | — | 1 | 6.90 |
| CHEMBL4218994 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4218769 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL4208018 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL4215817 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL4218245 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL4217261 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL4210359 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4215300 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4206514 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4209816 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL4213838 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL4210881 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL4205997 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4209443 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL4205708 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4211430 | — | IC50 | = | 2.17 | nM | 8.66 |
| CHEMBL4213305 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4209840 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4210568 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4208717 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4216080 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4213540 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4214345 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4215541 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4211934 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4210073 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4209789 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4205405 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4209139 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4204410 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL4218994 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL4214991 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL4215635 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL4207271 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL4211112 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL4205811 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL4211047 | — | IC50 | = | 4436.0 | nM | 5.35 |