Compound Detail
CHEMBL4209840
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Basic Information
| ChEMBL ID | CHEMBL4209840 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JBVMBAOZYQMABT-KRWDZBQOSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
432.6
MW (Da)
3.73
ALogP
7
HBA
1
HBD
75.4
PSA (Ų)
0.50
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.47
EC50 1 meas. best 7.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Calcium/calmodulin-dependent protein kinase type II subunit delta CHEMBL2801 | IC50 | 8.47 | 8.47 | 3.4 | 1 |
| Unchecked CHEMBL612545 | IC50 | 8.46 | 8.46 | 3.4 | 1 |
| Unchecked CHEMBL612545 | EC50 | 7.08 | 7.08 | 82.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Calcium/calmodulin-dependent protein kinase type II subunit delta | IC50 | = | 3.4 | nM | 8.47 | Inhibition of recombinant human full length His-tagged CaMK2delta expressed in b... | 29254643 |
| Unchecked | IC50 | = | 3.44 | nM | 8.46 | CaMKII delta Biochemical Assay: The biochemical activity of recombinant CaMKIIδ ... | - |
| Unchecked | EC50 | = | 82.5 | nM | 7.08 | CaMKII Cell-Based Activity: CaMKII activity in neonatal rat ventricular myocytes... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29254643 | 10.1016/j.bmcl.2017.10.040 | Calcium/calmodulin-dependent protein kinase type II subunit delta | 1 |
Data from ChEMBL 36 via Core Engine